James C. Kemp

Guo, James C

Under 1987 Federal Clean Water Act, Congress mandate has changed the concept in urban storm water management from storm water quantity control to both quantity and quality controls. The Best Management Practices (BMP's) have been developed for storm water designs to emphasize environmental concerns. Many studies have revealed that the traditional approach in storm water drainage has increased f...

A redox-mediated Kemp eliminase

The acid/base-catalysed Kemp elimination of 5-nitro-benzisoxazole forming 2-cyano-4-nitrophenol has long served as a design platform of enzymes with non-natural reactions, providing new mechanistic insights in protein science. Here we describe an alternative concept based on redox catalysis by P450-BM3, leading to the same Kemp product via a fundamentally different mechanism. QM/MM computations...

On Approximate Birkhoff-James Orthogonality and Approximate $ast$-orthogonality in $C^ast$-algebras

We offer a new definition of $varepsilon$-orthogonality in normed spaces, and we try to explain some properties of which. Also we introduce some types of $varepsilon$-orthogonality in an arbitrary  $C^ast$-algebra $mathcal{A}$, as a Hilbert $C^ast$-module over itself, and investigate some of its properties in such spaces. We state some results relating range-kernel orthogonality in $C^*$-algebras.

Kemp Eliminase Activity of Ketosteroid Isomerase.

Kemp eliminases represent the most successful class of computationally designed enzymes, with rate accelerations of up to 109-fold relative to the rate of the same reaction in aqueous solution. Nevertheless, several other systems such as micelles, catalytic antibodies, and cavitands are known to accelerate the Kemp elimination by several orders of magnitude. We found that the naturally occurrin...

Macroscopic Flow Models by James C . Williams 9